A New α-Pyrone Derivative, 6-[(E)-Hept-1-enyl]-α-pyrone, with Tyrosinase Inhibitory Activity from a Marine Isolate of the Fungus Botrytis

Abstract

Microorganisms such as bacteria, fungi, and blue-green algae have proven to be a rich source of new biologically active secondary metabolites.1 Marine microorganisms, particularly marine fungi, have recently drawn much attention as an important source of biologically active secondary metabolites. 2 Among marine fungi, those living in association with marine algae are promising sources of novel natural products due to their unique ecological niche. The association between algae and fungi appears to be highly developed since nearly one-third of all higher marine fungi described are namely algicolous or algae-associated organisms.3 Recently, marine-derived fungi have yielded unique biologically active metabolites, such as myrothenones,4 gliotoxin derivatives,5 and asperflavin ribofuranoside,6 suggesting that these organisms would be valuable producers of potential therapeutic agents.

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